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because advanced age 65 years is a predisposing factor for myopathy, including rhabdomyolysis, vytorin should be prescribed with caution in the elderly.

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patients new to treatment with vytorin who require more than the 10 40 mg dose should be switched to alternative agents.

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ezetimibe simvastatin marketed as vytorin , simvastatin marketed as zocor .
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In january 2008, merck schering plough pharmaceuticals — the maker of both zetia and vytorin — released the results of a study on the effects of the combination of ezetimibe and high-dose simvastatin versus simvastatin alone on the atherosclerotic process in patients with heterozygous familial hypercholesterolemia, called the enhance study.

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