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Active ingredient methotrexate contains an amount of methotrexate sodium equivalent to 2.

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1 years on background non-steroidal anti-inflammatory drugs nsaids and or prednisone, methotrexate given weekly at an oral dose of 10 mg m 2 provided significant clinical improvement compared to placebo as measured by either the physician s global assessment, or by a patient composite 25 reduction in the articular-severity score plus improvement in parent and physician global assessments of disease activity .

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there are two literature reports roenigk, 1969, and nyfors, 1978 describing large series n 204, 248 of psoriasis patients treated with methotrexate.

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the active metabolite is further metabolized and ex- to the deposition of methotrexate and its metabolites in creted through the kidneys and biliary tract.


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