Adverse gi effects generally appear during the first or second day of cefixime therapy and probably are direct effects of the drug and not the result of changes in bowel flora.
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respiratory fluoroquinolones moxifloxacin and levofloxacin , or a combination of an oral third-generation cephalosporins cefixime or cefpodoxime plus clindamycin are appropriate second-line agents.
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the sole comparative trial in this indication found cefixime administered after intravenous cefotaxime to be as effective as a full course of intravenous cefotaxime in patients with lrti of unspecified severity.
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however, the magnitude of the association between resistance and antimicrobial drug use was dwarfed by the magnitude of the association between resistance and geographic region and sex of sex partner, and use of an antimicrobial drug was not associated with reduced susceptibility to azithromycin, cefixime, and ceftriaxone.
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