In addition, in patients with severe hepatic cirrhosis, the bupropion cmax and auc were substantially increased mean difference by approximately 70 and 3-fold, respectively and more variable when compared to values in healthy volunteers; the mean bupropion half-life was also longer 29 hours in patients with severe hepatic cirrhosis vs 19 hours in healthy subjects .
2 treated with the combination of bupropion and nts and 1 subject 0.
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97 for comparison, bupropion and its three previously known primary metabolites, hydroxybupropion, threohydrobupropion, and erythrohydrobupropion represent 23 of a dose of bupropion excreted in urine.