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The long-term efficacy of paroxetine in treating obsessive compulsive disorder has been examined in three 24-week maintenance studies with relapse prevention design.

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5 percent of paroxetine patients gained greater than seven percent of body weight compared to 6.

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however, other published reports describe modest elevations less than 2-fold of clozapine and metabolite concentrations when clozapine was taken with paroxetine, fluoxetine, and sertraline.

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as with other ssris, paroxetine can cause mydriasis and should be used with caution in patients with narrow angle glaucoma or history of glaucoma.

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