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Ssris and snris, including paroxetine, have been associated with cases of clinically significant hyponatremia in elderly patients, who may be at greater risk for this adverse event see precautions , hyponatremia .

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neonates exposed to paroxetine tablets and other ssris or serotonin and norepinephrine reuptake inhibitors snris , late in the third trimester have developed complications requiring prolonged hospitalization, respiratory support, and tube feeding.

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procyclidine – daily oral dosing of paroxetine 30 mg qd increased steady-state auc0-24, cmax, and cmin values of procyclidine 5 mg oral qd by 35 , 37 , and 67 , respectively, compared to procyclidine alone at steady state.

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drugs metabolized by cyp2d6 – both paroxetine and fluoxetine inhibit the activity of cyp2d6 enzyme and may increase blood levels of concurrently administered drugs that also are metabolized by this enzyme.

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paroxetine affects neurotransmitters, the chemicals that nerves within the brain use to communicate with each other.
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