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However, in the postmarketing experience, patients taking bupropion to quit smoking have reported similar types of neuropsychiatric symptoms to those reported by patients in the clinical trials of bupropion for depression.

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bupropion was first synthesized by burroughs research in 1966, and patented by burroughs-wellcome later glaxo-wellcome in 1974.

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genotoxicity data indicate that bupropion is a weak bacterial mutagen, but not a mammalian mutagen, and therefore is of no concern as a human genotoxic agent.

Concomitant use of maois and bupropion is contraindicated because there is an increased risk of hypertensive reactions if bupropion is used concomitantly with maois.

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