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To the best of our knowledge, this is the first case report of bupropion-induced mood shift when used specifically for nicotine cessation in a nonbipolar patient.

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bupropion sr and sertraline produce comparable antidepressant and anti-anxiety effects and have equally rapid onset of symptom improvement in patients who suffer from both anxiety and depressive symptoms 22.

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when rats were administered bupropion at oral doses of up to 300 mg per kg per day approximately 7 times the mrhd on a mg per m 2 basis prior to mating and throughout pregnancy and lactation, there were no apparent adverse effects on offspring development.

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data from the international bupropion pregnancy registry 675 first trimester exposures and a retrospective cohort study using the united healthcare database 1,213 first trimester exposures did not show an increased risk for malformations overall.

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anaphylactoid anaphylactic reactions and symptoms suggestive of delayed hypersensitivity have been reported with bupropion, as well as rare spontaneous reports of erythema multiforme, stevens-johnson syndrome, and anaphylactic shock.

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56 this advisory was based on a review of anti-smoking products that identified 75 reports of suicidal adverse events for bupropion over ten years.
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