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The recommended oral dose of tretinoin is 45 mg m 2 day in all patients with acute promyelocytic leukaemia, including children and the elderly.

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in oral segment i and segment iii studies in rats with tretinoin, decreased survival of neonates and growth retardation were observed at doses in excess of 2 mg kg day 16 times the human topical dose adjusted for total body surface area .

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blood lipid determinations should be performed before accutane isotretinoin is given and then at intervals until the lipid response to accutane isotretinoin is established, which usually occurs within 4 weeks.

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tretinoin works best when used within a skin care program that includes protecting the treated skin from the sun.

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